Research
Animal-free Bioink for 3D Bioprinter
Animal-free Bioink for 3D Bioprinter
Animal-free Bioink for 3D Bioprinter
Hyaluronic acid (HA) and Alginate (Alg) hydrogel are polysaccharides from bacteria and seaweed, respectively. We have developed hydrogel, without addition of crosslinking agents. This composite hydrogel serves as network to entrap other macromolecules. The hydrogel exhibits shear-thinning behaviour, an important property for Bio-Ink in 3D bioprinting technology.
Synthetic/Natural Porous scaffold
Animal-free Bioink for 3D Bioprinter
Animal-free Bioink for 3D Bioprinter
Poly(vinyl) alcohol/Carboxymethyl Cellulose porous scaffolds are designed for chondrocyte culture. It combines advantages of synthetic polymer to natural polymer. The scaffold can be adjusted pore sizes and mechanical properties.
ECM hydrogels
Animal-free Bioink for 3D Bioprinter
ECM hydrogels
The Extracellular matrix-derived hydrogel (dECM hydrogel) holds promise to mimic physiological condition found in native tissue. We have developed hydrogels from extracellular matrix that provides biological cues to a newly grown tissue
Autologous Chondrocyte Implantation (ACI)
Autologous Chondrocyte Implantation (ACI)
Autologous Chondrocyte Implantation (ACI)
We have developed workflow to harvest cells and collaborated with King Chulalongkorn Memorial Hospital to grow cartilage tissues in GMP facilities. Patient's own cells will be expanded and re-grown in the lab before transplant back into defect areas. Target tissues are knee and ear cartilage.
Osteo-chondral grafts
Autologous Chondrocyte Implantation (ACI)
Autologous Chondrocyte Implantation (ACI)
A biphasic bone-cartilage tissue is composed of cartilage tissue on top of bone-like materials. The biphasic construct is expected to expedite healing process of osteo-chondral defects. Currently, we are searching for adhesive biomaterials at the interface between cartilage and bone.
Tracheal Tissue Engineering
Autologous Chondrocyte Implantation (ACI)
Tracheal Tissue Engineering
Our challenging milestone is to re-grow patient's own cells in donor's trachea, which is already removed cells (decellularization). This project is state-of-the-art by combining biology, engineering, and medicine.